Journal
FRONTIERS IN PSYCHOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyg.2015.01004
Keywords
sleep duration; inflammation; cognition; hospitalization; older adults
Categories
Funding
- National Institute on Aging [K23AG028452, K23AG045937]
- UCLA Claude D. Pepper Older Americans Independence Center [NIA 5P30 AG028748]
- National Center for Advancing Translational Sciences UCLA CTSI [UL1TR000124]
- VA Health Services Research Development [IIR 04-321-3]
- VA Advanced Geriatrics Fellowship Program
- Beeson Career Development in Aging research award program
- NIA
- AFAR
- John A. Hartford Foundation
- Atlantic Philanthropies
- VA Greater Los Angeles Healthcare System Geriatric Research, Education, and Clinical Center
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Examination of predictors of late-life cognitive functioning is particularly salient in at-risk older adults, such as those who have been recently hospitalized. Sleep and inflammation are independently related to late-life cognitive functioning. The potential role of sleep as a moderator of the relationship between inflammation and global cognitive functioning has not been adequately addressed. We examined the relationship between self-reported sleep duration, inflammatory markers, and general cognitive functioning in hospitalized older men. Older men (n = 135; Mean age = 72.9 +/- 9.7 years) were recruited from inpatient rehabilitation units at a VA Medical Center to participate in a cross-sectional study of sleep. Participants completed the Mini-Mental State Examination and Pittsburgh Sleep Quality Index, and underwent an 8 a.m. blood draw to measure inflammatory markers [i.e., C-reactive protein (CRP), tumor necrosis factor alpha (TNFot), soluble intercellular adhesion molecule-1 (5ICAM-1), and interleukin-6 (IL-6)]. Hierarchical regression analyses (controlling for age, education, race, depression, pain, health comorbidity, and BMI) revealed that higher levels of CRP and sICAM are associated with higher global cognitive functioning in older men with sleep duration >6h (beta = -0.19, beta = -0.18, p's < 0.05, respectively), but not in those with short sleep durations (p's > 0.05). In elderly hospitalized men, sleep duration moderates the association between inflammation and cognitive functioning. These findings have implications for the clinical care of older men within medical settings.
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