SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of Saturated N-Heterocycles

Saturated N-heterocycles can be found with increasing frequency in bioactive molecules, despite their limited commercial availability and challenging synthetic routes. A direct extension of aromatic cross-coupling methods to include saturated N-heterocycles remains elusive. However, the coupling of commercially available, or easily accessible, SnAP reagents with a wide range of aldehydes and ketones offers an alternative, practical, and versatile approach to saturated N-heterocycles.