Journal
EMBO REPORTS
Volume 19, Issue 5, Pages -Publisher
WILEY
DOI: 10.15252/embr.201744722
Keywords
PAI-1; senescence; stress granules; stress response
Categories
Funding
- Qatar National Research Fund (QNRF) [NPRP8-457-3-101]
- CIHR operating grant [MOP-89798]
- Defi Canderel Studentship Award, McGill University
- Fonds de recherche du Quebec-Sante (FRQS)
- NATIONAL INSTITUTE ON AGING [ZIAAG000511, ZIAAG000393] Funding Source: NIH RePORTER
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Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data reveal a novel interplay between senescence and the stress response that affects both the progression of senescence and the behavior of senescent cells. We show that constitutive exposure to stress induces the formation of stress granules (SGs) in proliferative and presenescent cells, but not in fully senescent cells. Stress granule assembly alone is sufficient to decrease the number of senescent cells without affecting the expression of bona fide senescence markers. SG-mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor-1 (PAI-1), a known promoter of senescence, to these entities. PAI-1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non-senescent state. Together, our data indicate that SGs may be targets of intervention to modulate senescence in order to impair or prevent its deleterious effects.
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