4.5 Article

A rapid, maskless 3D prototyping for fabrication of capillary circuits: Toward urinary protein detection

Journal

ELECTROPHORESIS
Volume 39, Issue 7, Pages 957-964

Publisher

WILEY
DOI: 10.1002/elps.201700449

Keywords

Capillary microfluidics; Laser ablation; Rapid prototyping; Ur

Funding

  1. Natural Science Foundation of Jiangsu Province [BK20170839]
  2. National Natural Science Foundation of China [51705257]

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Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point-of-care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, maskless 3D prototyping for fabrication of capillary fluidic circuits using laser engraving. The capillary circuits can be fabricated in a short amount of time (<10 min) without the requirements of clean-room facilities and photomasks. The advanced capillary components (e.g., trigger valves, retention valves and retention bursting valves) were fabricated, enabling the sequential liquid delivery and sample-reagent mixing. With the integration of smartphone-based detection platform, the microfluidic device can quantify the urinary protein via a colorimetric analysis. By eliminating the bulky and expensive equipment, this smartphone-based detection platform is portable for on-site quantitative detection.

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