Journal
ENDOCRINOLOGY AND METABOLISM
Volume 30, Issue 3, Pages 235-245Publisher
KOREAN ENDOCRINE SOC
DOI: 10.3803/EnM.2015.30.3.235
Keywords
Muscle; skeletal; Myokine; Obesity; Diabetes; Exercise; Metabolism
Categories
Funding
- American Diabetes Association [7-13-BS-004]
- National Institutes of Health [R01-NS084965, P01-DK049210]
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Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets.
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