Journal
NATURE REVIEWS CANCER
Volume 15, Issue 9, Pages 515-527Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3983
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Funding
- Science Foundation Ireland [06/CE/B1129]
- European Union FP7 (Seventh Framework Programme for Research and Technological Development) (Analysing and Striking the Sensitivities of Embryonal Tumours) [259348-2 ASSET]
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Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and to withstand therapeutic assaults is encoded by the structure and spatiotemporal dynamics of signal transduction networks. In this Review, we discuss recent concepts concerning how the rich signalling dynamics afforded by these networks are regulated and how they impinge on cancer cell proliferation, survival, invasiveness and drug resistance. Understanding this dynamic circuitry by mathematical modelling could pave the way to new therapeutic approaches and personalized treatments.
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