Journal
ELECTROCHIMICA ACTA
Volume 270, Issue -, Pages 369-377Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2018.03.102
Keywords
Voltammetry; Electrochemical sensors; Electropolymerization; p-Coumaric acid; L-cysteine
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Funding
- Russian Foundation for Basic Research [16-03-00507-a]
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Novel electrochemical sensor based on poly(p-coumaric acid) electrodeposited on the surface of multi-walled carbon nanotubes modified glassy carbon electrode (poly(p-coumaric acid)/MWNT/GCE) has been developed for the direct determination of L-cysteine. Poly(p-coumaric acid) has been obtained by potentiodynamic electrolysis under the optimized conditions (0.10 mM p-coumaric acid in 0.1 M NaOH using 5 cycles in the potential window of 0-1.0 V and the scan rate of 25 mV s(-1)) providing highest voltammetric response of L-cysteine. Sensor surface has been studied by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The porous structure of polymeric film provides 6.9-fold increase in effective surface area and 4.2-fold lower charge transfer resistance in comparison to GCE. Under conditions of DPV, the sensor response is linear in the ranges of 7.5-50 and 50-1000 mu M of L-cysteine with the detection and quantification limits of 1.1 and 3.6 mu M, respectively. The excellent sensor selectivity to L-cysteine in the presence of glucose, uric and ascorbic acids, dopamine, L-tyrosine and S-containing substances (homocysteine, glutathione, L-methionine, L-cystine and alpha-lipoic acid) has been observed. Applicability of the sensor to real samples analysis has been shown on example of human urine. (c) 2018 Elsevier Ltd. All rights reserved.
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