Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 85, Issue -, Pages 45-55Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2015.04.001
Keywords
SOD2; Redox state; Prostate cancer; Lung cancer; Colon cancer; Catalase; Glutathione; Peroxidase; Hydrogen peroxidase
Funding
- Instituto de Investigacion Carlos III [FISS-09-PS09/02204]
- MINECO - FEDER [BCU2012-38779]
- Universidad de Oviedo fellowship
- Institut Universitario de Oncologia del Principado de Asturias (IUOPA)
- ONCE Foundation fellowship programme A chance to the talent
- Obra Social y Cultural Cajastur
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The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results. While SOD2 downregulation was initially associated with tumor initiation and was proposed as a tumor suppressor gene, recent studies have reported that SOD2 might favor tumor progression and dissemination. To our knowledge this is the first time that changes in SOD2 expression in three different types of tumors, i.e., prostate, lung, and colon cancer, are studied by analyzing both SOD2 mRNA and protein levels in a total of 246 patients' samples. In prostate samples, SOD2 protein levels were also increased, especially in middle stage tumors. In the case of colon and lung tumors both mRNA and protein SOD2 levels were increased in malignant tissues compared to those in nontumor samples. More importantly, all metastases analyzed showed increased levels of SOD2 when compared to those of normal primary tissue and healthy adjacent tissue. Together, these results suggest that a common redox imbalance in these three types of tumor occurs at intermediate stages which then might favor migration and invasion, leading to a more aggressive cancer type. Consequently, the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis. (C) 2015 Elsevier Inc. All rights reserved,
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