Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 148, Issue -, Pages 467-472Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2017.10.059
Keywords
Reverse side-chain effect; Antimicrobial activity; Bacteria; Ionic liquids; Toxicity; Structure-activity relationship (SAR)
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Funding
- Austrian Federal Ministry of Science, Research and Economy
- National Foundation of Research, Technology and Development
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Increased interest in ionic liquids (ILs) is due to their designable and tunable unique physicochemical properties, which are utilized for a wide variety of chemical and biotechnological applications. ILs containing the Eris (pentafluoroethyl)trifluorophosphate ([FAP]) anion have been shown to have excellent hydrolytic, electrochemical and thermal stability and have been successfully used in various applications. In the present study the influence of the cation on the toxicity of the [FAP] anion was investigated. Due to the properties of [FAP] ILs, the IL-toxicity of seven cations with [FAP] compared to [CI] was examined by determination of minimum inhibitory (MIC) and minimum bactericidal concentrations (MSC) on six Gram-positive and six Gram-negative clinically relevant bacteria. For the first time, to our knowledge, the results provide evidence for a decrease in toxicity with increasing alkyl side-chain length, indicating that the combination of both ions is responsible for this 'reverse side-chain effect'. These findings could portend development of new non-toxic ILs as green alternatives to conventional organic solvents.
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