Journal
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
Volume 24, Issue 3, Pages 379-386Publisher
H E C PRESS, HEALTHY EATING CLUB PTY LTD
DOI: 10.6133/apjcn.2015.24.3.13
Keywords
malnutrition; deterioration; predict; outcome; acute stroke
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Funding
- Ministry of Science and Technology
- Ministry of Health of the People's Republic of China
- National 11th &12th Five-year S T Major Project [2006BAI01A11, 2011BAI08B01, 2011BAI08B02]
- National Science and Technology Major Project of China [2008ZX09312 -008]
- State Key Development Program for Basic Research of China [2009CB521905]
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2013BAI09B03]
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Objective: Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or malnutrition during hospitalisation could predict 3-month outcomes in acute stroke patients. Methods: During a 10-month period, patients who suffered their first stroke within 7 days after stroke onset were included in this prospective multi-centre study. The demographic parameters, stroke risk and severity factors, malnutrition risk factors and dysphagia were recorded. Nutritional status was assessed by 3 anthropometric and 3 biochemical indices. Changes in nutritional status were defined by comparing the admission values with the 2-week values. A Modified Rankin Scale score of 3-6 was defined as a poor outcome at the 3-month follow-up. Univariate and multiple logistic regression analyses were used to investigate the power of nutritional status changes in predicting poor patient outcomes. Results: Data from 760 patients were analysed. Poor outcomes were observed in 264 (34.7%) patients. Malnutrition prevalence was 3.8% at admission and 7.5% after 2-weeks in hospital, which could not predict 3-month outcome. Emerging malnutrition was observed in 36 patients (4.7%) during the 2-week hospitalisation period and independently predicted poor 3-month outcomes after adjusting for confounding factors (odds ratio 1.37, 95% confidence interval, 1.03-1.83). Conclusions: Emerging malnutrition during hospitalisation independently predicted poor 3-month outcomes in acute stroke patients in this study.
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