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Getting the genome in shape: the formation of loops, domains and compartments

Journal

GENOME BIOLOGY
Volume 16, Issue -, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/s13059-015-0730-1

Keywords

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Funding

  1. Dutch Scientific Organization (NWO) [91204082, 935170621]
  2. European Research Council [209700]
  3. European Research Council (ERC) [209700] Funding Source: European Research Council (ERC)

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The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

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