Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 88, Issue -, Pages 268-274Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2015.04.035
Keywords
Nrf2; Ionizing radiation; Reactive oxygen species; DNA repair; Cell and tissue damage
Funding
- NIH/NHLBI Grant [R01HL112286]
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Nrf2 is a transcription factor that promotes antioxidant and drug-metabolizing gene expression. It also regulates the transcription of genes involved in carbohydrate and lipid metabolism, NADPH regeneration, and heme and iron metabolism, as well as proteasome metabolism. Emerging research has identified Nrf2 as a critical factor for promoting survival of mammalian cells subjected to ionizing radiation. At a mechanistic level, Nrf2 promotes the repair of DNA damage and drives detoxification of superoxide that is generated hours to days after irradiation. This review summarizes research in these areas and discusses targeting of Nrf2 in radiation-resistant cancer and Nrf2's role in mitigating acute radiation syndrome. (C) 2015 Elsevier Inc. All rights reserved.
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