Journal
DRUG DISCOVERY TODAY
Volume 23, Issue 6, Pages 1274-1284Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2018.04.009
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Funding
- FCT PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) [PD/BD/127813/2016]
- Tertiary Education Fund (TETFUND) Nigeria
- FCT/MCTES [UID/DTP/04138/2013]
- Fundação para a Ciência e a Tecnologia [PD/BD/127813/2016] Funding Source: FCT
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This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets.
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