Journal
DRUG DISCOVERY TODAY
Volume 23, Issue 2, Pages 375-381Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2017.11.004
Keywords
-
Categories
Funding
- Heart and Stroke Foundation of Canada [114887]
Ask authors/readers for more resources
Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available