Journal
DRUG DISCOVERY TODAY
Volume 23, Issue 5, Pages 1126-1138Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2018.02.009
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Funding
- National Natural Science Foundation of China [81402500]
- National Key Specialty Construction Project of Clinical Pharmacy [30305030698]
- Youth Science and Technology Foundation of Science and Technology Department of Sichuan Province [2016JQ0031]
- Thousand Talents Plan for Young Professionals
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Targeted drug delivery for cancer therapy is expected to enhance therapeutic efficacy with minimized side effects, where the ligand-receptor recognition serves as a common targeting approach. Various ligands have been reported and carbohydrates, one of the crucial structures of tumor cell membranes, have been demonstrated effective for cell-selective binding. Hence, glycosylation-mediated cancer targeted drug nanocarriers have received increasing attention in recent years. This review surveys a variety of glycosylated drug delivery systems as well as their applications for cancer therapy. Their challenges, opportunities, and future perspectives are also discussed in the end.
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