Journal
DRUG DELIVERY
Volume 25, Issue 1, Pages 1137-1146Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2018.1472678
Keywords
Mesoporous silica nanoparticles; dual release; doxorubicin; camptothecin; combination therapy
Categories
Funding
- IQS
- Generalitat de Catalunya for the consolidated Research Group Grant [(SGR) 1170]
Ask authors/readers for more resources
A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide-polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place. In vitro cytotoxicity tests have demonstrated that this DDS can deliver efficiently DOX and CPT for combination therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available