Journal
DRUG DELIVERY
Volume 25, Issue 1, Pages 1319-1327Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2018.1477857
Keywords
Drug delivery system; immunotherapy; nano; peptide vaccine; tumor
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In the past 40years, the nanoparticle drug delivery system for tumor peptide vaccines has been widely studied which also reached a splendid result. Nanomaterial can enhance the targeting of vaccines, help vaccines enter the cells and trigger immune response by themselves. They also help in increasing cellular uptake, improving permeability and efficacy. Currently, several categories of nanopreparation, such as liposome, polymeric micelle, polymeric nanoparticle, gold nanoparticle and so on, are proved that they are appropriate for peptide vaccines. This review we discussed the possible mechanisms of nanomaterial's action on the regulation of immunological functions and several major applications of this advanced drug delivery system for tumor peptide vaccine.
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