Journal
DRUG DELIVERY
Volume 25, Issue 1, Pages 198-209Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2017.1422298
Keywords
Mechanical ball milling; solid dispersion; curcumin; self-micelle; cytotoxic activity; bioavailability
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Funding
- International S&T Cooperation Program of China [2013DFR40560]
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An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na(2)GA) was prepared by mechanical ball milling. Curcumin loaded micelles were self-formed by Na(2)GA when SD dissolved in water. The physical properties of Cur SD in solid state were characterized by differential scanning calorimetry, X-ray diffraction studies, and scanning electron microscope. The characteristics of the sample solutions were analyzed by reverse phase HPLC, UV-visible spectroscopy, H-1 NMR spectroscopy, gel permeation LC, and transmission electron microscopy. In vitro cytotoxic tests demonstrated that Cur SD induced higher cytotoxicity against glioblastoma U-87MG cells than free Cur. Besides, an improvement of membrane permeability of Cur SD was confirmed by parallel artificial membrane permeability assay. Further pharmacokinetic study of this SD formulation in rat showed a significant approximate to 19-fold increase of bioavailability as comparing to free Cur. Thus, Cur SD provide a more potent and efficacious formulation for Cur oral delivery.
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