Journal
CHINESE JOURNAL OF CANCER
Volume 34, Issue -, Pages -Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.1186/s40880-015-0052-4
Keywords
Wnt3a; The Wnt signaling pathway; Cancer
Categories
Funding
- National Natural Science Foundation of China (NSFC) Key Project [81130046]
- NSFC projects [81171993, 81272415, 81272340, 81472386]
- National Natural Science Foundation of Guangxi Key Projects [2013GXNSFEA053004, 2012GXNS-FCB053004]
- Guangxi Projects [1355004-5]
- Guangxi Ministry of Education [201202ZD022, 201201ZD004]
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Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.
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