B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Background: Primary central nervous system lymphoma (PCNSL) is an uncommon tumoi in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as sentinel lesions.