Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 92, Issue 3, Pages 210-213Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2018.06.009
Keywords
Next-generation sequencing; Molecular diagnostics; Noninvasive; Diagnostic biopsy; Invasive fungal infection
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Funding
- Karius, Inc., Redwood City, CA
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Diagnosis of life-threatening deep-seated infections currently requires invasive sampling of the infected tissue to provide a microbiologic diagnosis. These procedures can lead to high morbidity in patients and add to healthcare costs. Here we describe a novel next-generation sequencing assay that was used to detect pathogen-derived cell free DNA in peripheral blood of patients with biopsy-proven invasive fungal infections. The noninvasive nature of this approach could provide rapid, actionable treatment information for invasive fungal infections when a biopsy is not possible. (C) 2018 The Authors. Published by Elsevier Inc.
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