Journal
DIABETIC MEDICINE
Volume 35, Issue 7, Pages 895-902Publisher
WILEY
DOI: 10.1111/dme.13634
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AimPeripheral artery disease is common in people with diabetes-related foot ulceration and is a risk factor for amputation. The best method for the detection or exclusion of peripheral artery disease is unknown. This study investigated the utility of clinical examination and non-invasive bedside tests in screening for peripheral artery disease in diabetes-related foot ulceration. MethodsSome 60 people presenting with new-onset ulceration participated. Accuracy of pulses, ankle pressure, toe pressure, toe-brachial index (TBI), ankle-brachial pressure index (ABPI), pole test at ankle, transcutaneous oxygen pressure and distal tibial waveform on ultrasound were examined. The gold standard diagnostic test used was > 50% stenosis in any artery or monophasic flow distal to calcification in any ipsilateral vessel on duplex ultrasound. ResultsThe negative and positive likelihood ratios of pedal pulse assessment (0.75, 1.38) and the other clinical assessment tools were poor. The negative and positive likelihood ratios of ABPI (0.53, 1.69), transcutaneous oxygen pressure (1.10, 0.81) and ankle pressure (0.67, 2.25) were unsatisfactory. The lowest negative likelihood ratios were for tibial waveform assessment (0.15) and TBI (0.24). The highest positive likelihood ratios were for toe pressure (17.55) and pole test at the ankle (10.29) but the negative likelihood ratios were poor at 0.56 and 0.74. ConclusionsPulse assessment and ABPI have limited utility in the detection of peripheral artery disease in people with diabetes foot ulceration. TBI and distal tibial waveforms are useful for selecting those needing diagnostic testing. What's new? We evaluated the utility of clinical examination and non-invasive bedside tests in screening for peripheral artery disease in people with diabetes. This study is unique in both the wide variety of tests investigated and that all participants had ulceration. Screening tests must reliably exclude the disease, as it is associated with both failure to heal and major amputation. We demonstrate that only toe-brachial index and tibial waveform analysis would be considered suitable for screening to exclude peripheral artery disease. Simple bedside clinical examinations such as pulse assessment are unreliable in excluding peripheral artery disease in this cohort.
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