Journal
MATHEMATICAL BIOSCIENCES AND ENGINEERING
Volume 12, Issue 6, Pages 1203-1217Publisher
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/mbe.2015.12.1203
Keywords
Cancer; immune system; Interleukin 27; Interleukin 35
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The cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer. CD8(+) T cells are activated by IL-27 cytokine and they kill tumor cells. Regulatory T cells produce IL-35 which promotes cancer cells by enhancing angiogenesis, and inhibit CD8(+) T cells via TGF-beta production. Hence injections of IL-27 and anti-IL-35 are both potentially antitumor drugs. The models presented here are based on experimental mouse experiments, and their simulations agree with these experiments. The models are used to suggest effective schedules for drug treatment.
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