Journal
AIDS AND BEHAVIOR
Volume 19, Issue 10, Pages 1801-1817Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10461-015-1054-6
Keywords
Antiretroviral therapy; Intervention; HIV/AIDS; Disparities; Motivational interviewing
Funding
- National Institutes of Mental Health [R34MH093352]
- Center for Drug Use and HIV Research (CDUHR) [P30 DA011041]
- NIAID/NIH [RO1AI098472]
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Nationally up to 60 % of persons living with HIV are neither taking antiretroviral therapy (ART) nor well engaged in HIV care, mainly racial/ethnic minorities. This study examined a new culturally targeted multi-component intervention to address emotional, attitudinal, and social/structural barriers to ART initiation and HIV care. Participants (N = 95) were African American/Black and Latino adults with CD4 < 500 cells/mm(3) not taking ART, randomized 1:1 to intervention or control arms, the latter receiving treatment as usual. Primary endpoints were adherence, evaluated via ART concentrations in hair samples, and HIV viral load suppression. The intervention was feasible and acceptable. Eight months post-baseline, intervention participants tended to be more likely to evidence good (that is, 7 days/week) adherence (60 vs. 26.7 %; p = 0.087; OR = 3.95), and had lower viral load levels than controls (t(22) = 2.29, p = 0.032; OR = 5.20), both large effect sizes. This highly promising intervention merits further study.
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