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Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

Journal

DEVELOPMENTAL CELL
Volume 44, Issue 3, Pages 284-296

Publisher

CELL PRESS
DOI: 10.1016/j.devcel.2018.01.009

Keywords

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Funding

  1. MEXT/JSPS KAKENHI [26114002, 16H02505, 17H03673, 15H05862]
  2. Takeda Science Foundation
  3. Naito Foundation
  4. Japan Agency for Medical Research and Development
  5. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007790] Funding Source: NIH RePORTER

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Epithelial tissues robustly respond to internal and external stressors via dynamic cellular rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by removing apoptotic cells, orchestrating morphogenesis, and mediating competitive cellular battles during tumorigenesis. Here, we delineate the diverse functions of cell extrusion during development and disease. We emphasize the expanding role for apoptotic cell extrusion in exerting morphogenetic forces, as well as the strong intersection of cell extrusion with cell competition, a homeostatic mechanism that eliminates aberrant or unfit cells. While cell competition and extrusion can exert potent, tumor-suppressive effects, dysregulation of either critical homeostatic program can fuel cancer progression.

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