Journal
DEVELOPMENTAL CELL
Volume 44, Issue 5, Pages 537-539Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2018.02.019
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FOXO3a, a member of the Forkhead transcription factor family, has roles in apoptosis and autophagy. In this issue of Developmental Cell, Fitzwalter et al. (2018) describe how the blockade of FOXO3a turnover, which normally occurs through autophagy, sensitizes cancer cells to apoptosis through FOXO3a-mediated stimulation of pro-apoptotic PUMA/BBC3 expression.
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