Journal
DEVELOPMENTAL CELL
Volume 44, Issue 6, Pages 679-+Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2018.02.024
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Funding
- New York Stem Cell Foundation
- NIH-National Heart, Lung, and Blood Institute Early Career Research New Faculty (P30) award [5P30HL101287-02]
- RO1 from NHLBI [RO1HL118185]
- Ludwig Cancer Center at Harvard
- Massachusetts Eye and Ear Infirmary
- Harvard Stem Cell Institute (HSCI) Junior Investigator grant
- NIH Medical Scientist Training Program [T32GM007205]
- Medical Scientist Training Program [GM007101]
- career development award from NHLBI/NIH [R00HL127181]
- NATIONAL CANCER INSTITUTE [ZIABC005522] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL127181, R01HL118185, K99HL127181, P30HL101287] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007205] Funding Source: NIH RePORTER
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We show that the loss or gain of transcription factor programs that govern embryonic cell-fate specification is associated with a form of tumor plasticity characterized by the acquisition of alternative cell fates normally characteristic of adjacent organs. In human non-small cell lung cancers, downregulation of the lung lineage-specifying TF NKX2-1 is associated with tumors bearing features of various gut tissues. Loss of Nkx2-1 from murine alveolar, but not airway, epithelium results in conversion of lung cells to gastric-like cells. Superimposing oncogenic Kras activation enables further plasticity in both alveolar and airway epithelium, producing tumors that adopt midgut and hindgut fates. Conversely, coupling Nkx2-1 loss with foregut lineage-specifying SOX2 overexpression drives the formation of squamous cancers with features of esophageal differentiation. These findings demonstrate that elements of pathologic tumor plasticity mirror the normal developmental history of organs in that cancer cells acquire cell fates associated with developmentally related neighboring organs.
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