Journal
DEVELOPMENTAL CELL
Volume 45, Issue 3, Pages 289-301Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2018.03.021
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Funding
- Research Foundation Flanders (FWO)
- LERN/FDRS
- FWO [IUAP7/03, G.0598.12, G.0532.10, G.0817.11, G.0834.13, 1.5.202.10.N]
- Foundation Leducq Transatlantic Network (ARTEMIS)
- AXA Research Fund [1465]
- Foundation against Cancer
- ERC Advanced Research Grant [EU-ERC269073]
- Flemish Government
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The lymphatic system has been less well characterized than the blood vascular system; however, work in recent years has uncovered novel regulators and non-venous lineages that contribute to lymphatic formation in various organs. Further, the identification of organ-specific lymphatic beds underscores their potential interaction with organ development and function, and highlights the possibility of targeting these organ-specific lymphatics beds in disease. This review focuses on newly described metabolic and epigenetic regulators of lymphangiogenesis and the interplay between lymphatic development and function in a number of major organ systems.
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