Journal
DEVELOPMENTAL BIOLOGY
Volume 433, Issue 2, Pages 227-239Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2017.08.022
Keywords
Coding and non-coding RNAseq; Axolotl; Regenerative tissues; MicroRNAs
Categories
Funding
- Swedish International Research links grant [2014-9040-114152-32]
- UC MEXUS Collaborative Grant [2011-UC MEXUS-19941-44-OAC7]
- Consejo Nacional de Ciencia y Tecnologia grant: Fronteras de la Ciencia Grant CONACYT [FOINS-301]
- Consejo Nacional de Ciencia y Tecnologia grant: Fronteras de la Ciencia Grant Ciencia Basica [I0017-CB-2015-01-000000000252126]
Ask authors/readers for more resources
The axolotl (Ambystoma mexicanum) is the vertebrate model system with the highest regeneration capacity. Experimental tools established over the past 100 years have been fundamental to start unraveling the cellular and molecular basis of tissue and limb regeneration. In the absence of a reference genome for the Axolotl, transcriptomic analysis become fundamental to understand the genetic basis of regeneration. Here we present one of the most diverse transcriptomic data sets for Axolotl by profiling coding and non coding RNAs from diverse tissues. We reconstructed a population of 115,906 putative protein coding mRNAs as full ORFs (including isoforms). We also identified 352 conserved miRNAs and 297 novel putative mature miRNAs. Systematic enrichment analysis of gene expression allowed us to identify tissue-specific protein-coding transcripts. We also found putative novel and conserved microRNAs which potentially target mRNAs which are reported as important disease candidates in heart and liver.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available