Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 86, Issue -, Pages 26-33Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2018.04.015
Keywords
Antifungal peptide; Constitutive immune defense; Thaumatin-like peptide; Beauveria bassiana; Tenebrio molitor
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Funding
- ERC [260986]
- University of Copenhagen
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Antimicrobial peptides have been well studied in the context of bacterial infections. Antifungal peptides have received comparatively less attention. Fungal pathogens of insects and their hosts represent a unique opportunity to study host-pathogen interactions due to the million of years of co-evolution they share. In this study, we investigated role of a constitutively expressed thaumatin-like peptide with antifungal activity expressed by the mealworm beetle Tenebrio molitor, named Tenecin 3, during a natural infection with the entomopathogenic fungus Beauveria bassiana. We monitored the effect of the expression of Tenecin 3 on the survival of infected hosts as well as on the progression of the fungal infection inside the host. Finally, we tested the activity of Tenecin 3 against B. bassiana. These findings could help improving biocontrol strategies and help understanding the evolution of antifungal peptides as a defense mechanism. (C) 2018 Elsevier Ltd. All rights reserved.
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