Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 83, Issue -, Pages 70-79Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2017.11.020
Keywords
Lectins; Lepidoptera; Carbohydrate-recognition domain; Immune response; Pattern recognition
Categories
Funding
- National Natural Science Foundation of China [31472019, 31402017, 31501639]
- Distinguished Young Scholars at Fujian Agriculture and Forestry University [XJQ201624]
- Natural Science Foundation of Anhui Province [1508085QC51]
- Anhui Agricultural University [YJ2013-16]
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C-type lectins (CDs) are a family of proteins that contain characteristic modules of carbohydrate recognition domains (CRDs) and they possess the binding activity to ligands in a calcium-dependent manner. CFCs play important roles in animal immune responses, and in insects, they are involved in opsonization, nodule formation, agglutination, encapsulation, melanization, and prophenoloxidase activation, as well as in maintaining gut microbiome homeostasis. In this review, we will summarize insect CTLs, compare the properties of insect CTLs with vertebrate CTLs, and focus mainly on the domain organization and functions of insect CTLs in innate immunity. (C) 2017 Elsevier Ltd. All rights reserved.
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