Journal
DEVELOPMENT
Volume 145, Issue 2, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.139691
Keywords
Bone marrow; Hematopoietic stem cell; Hemogenic endothelium; Microenvironment; Niche
Categories
Funding
- National Institutes of Health [DK056638, HL069438]
- Leukemia and Lymphoma Society [LLS-TRP 6475-15]
- New York State Department of Health [NYSTEM IIRP C029570, C029154]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL069438] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK112976, R01DK056638] Funding Source: NIH RePORTER
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Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.
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