Journal
NATURE REVIEWS CANCER
Volume 15, Issue 10, Pages 593-607Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3984
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Funding
- European Community's Seventh Framework Programme (MODHEP consortium)
- European Research Council
- Italian Health Ministry
- Italian Association for Cancer Research (AIRC)
- Worldwide Cancer Research
- AIRC
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Two opposing models have been proposed to describe the function of the MYC oncoprotein in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active loci; the other that MYC differentially controls discrete sets of genes, the products of which affect global transcript levels. Here, we argue that differential gene regulation by MYC is the sole unifying model that is consistent with all available data. Among other effects, MYC endows cells with physiological and metabolic changes that have the potential to feed back on global RNA production, processing and turnover. The field is progressing steadily towards a full characterization of the MYC-regulated genes and pathways that mediate these biological effects and - by the same token - endow MYC with its pervasive oncogenic potential.
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