Journal
DEVELOPMENT
Volume 145, Issue 1, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.152595
Keywords
Amino acids; mTOR; Metabolism; Signaling; Stem cell
Categories
Funding
- Cancer Prevention Research Institute of Texas Scholar Recruitment of First-Time Tenure-Track Faculty Member [RR150032]
- Cancer Prevention Research Institute of Texas High-Impact/High-Risk Research Award [RP160713]
- Welch Foundation [I-1927-20170325]
- University of Texas Southwestern President's Research Council Distinguished Researcher Award
- National Institutes of Health, Pharmacological Sciences Training Grant [GM007062]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007062] Funding Source: NIH RePORTER
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The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTORin promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overviewofmTORsignaling and its role inmurine and human stemand progenitor cells.
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