Journal
EMERGING INFECTIOUS DISEASES
Volume 21, Issue 10, Pages 1742-1750Publisher
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2110.141660
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Funding
- Peruvian Ministry of Health
- Bolivian Ministy of Health
- National Institute of Allergy and Infectious Disease through the Western Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research
- National Institutes of Health (NIH) [U54 AIO57156]
- Robert E. Shope International Fellowship in Infectious Diseases from the American Society of Tropical Medicine and Hygiene
- US Department of Defense Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [847705.82000.25GB.B0016]
- James W. McLaughlin endowment fund
- NIH [HH-SN272201000040I/HHSN27200004/D04]
- El Fondo Nacional de Ciencia, Tecnologia e Innovacion [Mision Ciencia 2008000911-4]
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In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estacion village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing approximate to 17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged approximate to 150 years ago and genotype diverged N approximate to 250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.
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