Journal
BRAZILIAN JOURNAL OF MICROBIOLOGY
Volume 46, Issue 4, Pages 1161-1164Publisher
SPRINGER
DOI: 10.1590/S1517-838246420140873
Keywords
Leptospira interrogans; renal colonization; natural reservoirs; Rattus norvegicus
Categories
Funding
- Oswaldo Cruz Foundation (FIOCRUZ)
- Secretariat of Health Surveillance of the State of Bahia
- National Institutes of Health [R01 AI052473, R01 TW009504, R25 TW009338]
- Wellcome Trust [102330/Z/13/Z]
- Wellcome Trust [102330/Z/13/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
We evaluated the renal colonization by Leptospira interrogans in Rattus norvegicus (rats), as it is the major natural reservoir of urban leptospirosis. We caught 72 R. norvegicus, out of which 32 were found to be positive for L. interrogans by immunofluorescence assay. From these rats, we selected 17 and divided them into six groups based on the mass-age/sex. We performed the immunohistochemistry test against L. interrogans in the kidney sections of the rats and systematically counted the colonized tubules (CTs) in 20 fields. The proportion of positive fields varied from 5% to 95%. The number of CTs in 20 fields varied from 0.5 to 85.5. These differences were not related to age or sex of the animals. The characterization of leptospiral colonization patterns in the natural reservoirs is important to better understand the host-pathogen interactions in leptospirosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available