Journal
DALTON TRANSACTIONS
Volume 47, Issue 31, Pages 10463-10472Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8dt01238e
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Funding
- Center for Integrated Protein Science Munich
- European Research Council (ERC) [VOLCANO 669371]
- [SFB 749]
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Interest in the bioinorganic chemistry of lanthanides is growing rapidly as more and more lanthanide-dependent bacteria are being discovered. Especially the earlier lanthanides have been shown to be preferentially utilized by bacteria that need these Lewis acids as cofactors in their alcohol dehydrogenase enzymes. Here, we investigate the impact of the lanthanide ions lanthanum(III) to lutetium(III) (excluding Pm) on the catalytic parameters (v(max), K-M, k(cat)/K-M) of a methanol dehydrogenase (MDH) isolated from Methylacidiphilum fumariolicum SolV. Kinetic experiments and DFT calculations were used to discuss why only the earlier lanthanides (La-Gd) promote high MDH activity. Impact of Lewis acidity, coordination number preferences, stability constants and other properties that are a direct result of the lanthanide contraction are discussed in light of the two proposed mechanisms for MDH.
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