4.5 Article

Intracellular regulation of TNF activity in health and disease

Journal

CYTOKINE
Volume 101, Issue -, Pages 26-32

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.08.035

Keywords

TNF; NF-kB; Apoptosis; Necroptosis; RIP kinases; Ubiquitin

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Tumor Necrosis Factor alpha (TNF alpha, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation and regulates metabolic processes. Whereas TNF-induced NF-kappa B and MAP pro-survival kinase activities constitute its major biochemical functions, TNF can also stimulate cell death in certain pathological situations. TNF-induced signal transduction pathways are tightly regulated through ubiquitination and phosphorylation of molecules partaking in all TNF-dependent membrane-associated and intracellular protein signaling complexes. Deregulated TNF signaling in individuals carrying naturally occurring genetic mutations in proteins that mediate TNF signaling, or in corresponding genetically modified animal models, results in severe pathologies. In this review we will describe the current knowledge of TNF signaling and its relevance for human health. (C) 2016 Elsevier Ltd. All rights reserved.

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