Journal
CYTOKINE
Volume 111, Issue -, Pages 460-469Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2018.05.035
Keywords
Interleukin-10; Interleukin-6; Obesity; High-intensity interval training; Moderate-intensity continuous training
Funding
- Canadian Institutes of Health Research (CIHR) [333266]
- Natural Sciences and Engineering Council of Canada (NSERC) [DG-435807]
- CIHR [201309]
- Michael Smith Foundation for Health Research (MSFHR) Scholar Award [5917]
- CIHR New Investigator Award [MSH-141980]
- MSFHR Scholar Award [16890]
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A key pathological component of obesity is chronic low-grade inflammation, which is propagated by infiltration of immune cells into tissues and overproduction of pro-inflammatory cytokines. Cytokines that possess anti-inflammatory properties, such as interleukin (IL)-10 and IL6, may also play an important role. This study was designed to determine the impact of short-term exercise on the anti-inflammatory action of IL10 and IL6. Thirty-three inactive obese adults were randomized to two weeks of high-intensity interval training (HIIT) or moderate intensity continuous training (MICT). Fasting blood samples were collected before and after training. Lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha production was measured in whole blood cultures in the presence or absence of IL10 or IL6. IL10 and IL6 receptor expression were measured on circulating monocytes, neutrophils, and T cells. HIIT and MICT reduced the ability of IL10 to inhibit LPS-induced TNF alpha production, with a greater effect with HIIT (Group x Time and IL10 x Time interactions, p's < 0.05). This reduction in 1110 function was not explained by altered IL10R1 expression, which was unchanged after training (p > 0.05). HIIT and MICT differentially affected IL6 function (Group x Time and IL6 x Time interactions, p's < 0.05) with evidence of reductions in the anti-inflammatory ability of IL6 with HIIT. Neither HIIT nor MICT altered levels of circulating IL10, IL6, or TNF alpha. The impact of short-term HIIT and MICT resulted in differential effects on anti-inflammatory cytokine function. The clinical implications remain to be determined but these novel findings indicate that measuring anti-inflammatory cytokine action could reveal important immunomodulatory effects of exercise.
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