Journal
CURRENT VASCULAR PHARMACOLOGY
Volume 16, Issue 4, Pages 355-360Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570161115666170609102506
Keywords
Vitamin D; acute myocardial infarction; matrix metalloproteinases; leptin; non HDL-cholesterol; vulnerable plaque
Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2013-1150]
- Universidad de Buenos Aires [UBACYT 20020150100042BA]
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Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction. Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined. Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003). Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.
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