Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 18, Issue 9, Pages 750-758Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026618666180528124414
Keywords
Anti tuberculosis drugs; Tuberculosis; Multi-target drugs; Targeting; Inhibition; Mycobacterium tuberculosis
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)
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Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
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