Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 20, Issue 3, Pages 240-250Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203719666180612084615
Keywords
Melittin; bee venom; melittin derivatives; anti-tumor effect; hemolysis; clinical applications
Categories
Funding
- National Natural Science Foundation of China [30772887]
- Science and Technology Commission of Shanghai Municipality [15ZR1412800]
Ask authors/readers for more resources
Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive therapeutic candidate for human diseases. However, melittin induces extensive hemolysis, a severe side effect that dampens its future development and clinical application. Thus, studies of melittin derivatives and new drug delivery systems have been conducted to explore approaches for optimizing the efficacy of this compound, while reducing its toxicity. A number of reviews have focused on each side, respectively. In this review, we summarize the research progress on the anti-tumor effects of melittin and its derivatives, and discuss its future potential clinical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available