Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 20, Issue 2, Pages 139-144Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203719666180514150921
Keywords
Lactoferrin (Lf); iron-binding activity; immunomodulatory function; anti-microbial effect; anti-viral effect; antioxidant effect; anti-cancer effect; application
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Funding
- National Key Research and Development Program of China [2016YFD0500507, ASTIP-IAS07]
- Central Public Interest Scientific Institution Basal Research Fund [2016ywf-yb-3]
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Lactoferrin (lactotransferrin; Lf) is an iron-binding glycoprotein and one of the most important bioactivators in milk and other external secretions. It has numerous biological roles, including the regulation of iron absorption and modulation of immune responses, and has anti-microbial, anti-viral, antioxidant, anti-cancer, and anti-inflammatory activities. Lf regulates the quantity of iron absorbed in the intestine via its role in iron transport and can also chelate iron, directly or indirectly. Notably, it has been used as an adjuvant therapy for some intestinal diseases. It is now used in nutraceutical-supplemented infant formula and other food products. This article reviews the content, distribution, physiologic functions and current applications of Lf, and aims to shed light on future prospects for additional applications of Lf.
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