Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 23, Issue 44, Pages 6784-6794Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612823666171018114331
Keywords
IAM chromatography; blood-brain barrier; skin permeability; oral bioavailability
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Funding
- Medical University of Lodz [503/3-016-03/503-31-001]
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A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.
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