Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 19, Issue 2, Pages 163-174Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201019666180427111735
Keywords
Methamphetamine; prenatal exposure; pregnancy; neonate; meconium; hair; case report; toxicity
Funding
- Fondo de Investigacion Sanitaria, Institute de Salud Carlos III, Ministerio de Educacion y Ciencia, Spain [PI15/00251]
Ask authors/readers for more resources
Background: Methamphetamine misuse represents an increasing global public health problem. Its consumption during pregnancy becomes a relevant issue, since it has clinical consequences for the child's health and the pregnant woman. Despite this, there are only few data in the literature that include analytical results in the matrices used to detect prenatal exposure. Objectives: 1) Present a case report of prenatal methamphetamine exposure with toxicological analytical confirmation in biological matrices; and 2) Perform a compilation of prenatal methamphetamine exposure studies and case reports which include toxicological analytical results. Methods: Prenatal methamphetamine exposure was confirmed using a traditional screen with reflex approach. Methamphetamine and amphetamine were quantified in urine, meconium and hair samples of the neonate and mother by gas chromatography-mass spectrometry. Also, a detailed revision of the existent literature that provides information on the analytical toxicology results has been included. Results: In the neonatal biological matrices test results of methamphetamine/amphetamine were: urine 2,966.43/1,638.71 ng/mL, meconium 1,4501<0.1 ng/g and hair 36.54/9.66 ng/mg. In the maternal biological matrices, test results were: urine 13,393.89/3,074.95 ng/mL and hair 11.29/3.37 ng/mg (0-3 cm), 4.68/2.58 (3-6 cm), 6.43/3.13 ng/mg (6-9 cm) and 4.72/2.49 ng/mg (9-12 cm). These results confirm a recent and continued regular substance use throughout pregnancy including delivery. Conclusion: The data provided will be useful for clinical purposes to improve the diagnostic and follow-up of acute and chronic intoxications. Additionally, results will be used to support interpretations in the field of forensic and legal medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available