Journal
CURRENT ORGANIC CHEMISTRY
Volume 22, Issue 3, Pages 268-275Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272821666170817105019
Keywords
Multi component reactions; reactions under pressure; hetero-tricyclic systems; 2-phenylhydrazones; aldehydes; acetone
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Funding
- Kuwait University Research Administration [SC13/13]
- GFS [GS 01/01, GS 01/03, GS 01/05, GS 02/10, GS 03/08]
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Background and Methodology: A series of pyridazino[5,4,3-de][1,6]naphthyridine derivatives of a new ring system (11a-k, 29a,b) were synthesized via novel multicomponent reaction under high pressure from 2-phenylhydrazono derivatives (1a-d), malononitrile and aromatic aldehydes (10a-h) or acetone (28). Conclusion: The structure of reaction products could be established by X-ray crystallography and a mechanism of reaction is proposed.
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