Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 51, Issue -, Pages 141-148Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.04.006
Keywords
-
Categories
Funding
- National Institutes of Health [R01 DA036887, R01 CA194864]
Ask authors/readers for more resources
Despite increasing demands for antibodies to post translational modifications (PTMs), fundamental difficulties in molecular recognition of PTMs hinder the generation of highly functional anti-PTM antibodies using conventional methods. Recently, advanced approaches in protein engineering and design that have been established for biologics development were applied to successfully generating highly functional anti-PTM antibodies. Furthermore, structural analyses of anti-PTM antibodies revealed unprecedented binding modes that substantially increased the antigen-binding surface. These features deepen the understanding of mechanisms underlying specific recognition of PTMs, which may lead to more effective approaches for generating anti-PTM antibodies with exquisite specificity and high affinity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available