Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 41, Issue -, Pages 34-41Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2018.03.014
Keywords
-
Categories
Funding
- European Union's Seventh Framework Programme IFP7/2007-2013] [280873 ADITEC]
Ask authors/readers for more resources
Immunosenescence contributes to increased incidence and severity of many infections in old age and is responsible for impaired immunogenicity and efficacy of vaccines. Adjuvants are one strategy to enhance immunogenicity of vaccines. The oil-in-water emulsions MF59TM and AS03, as well as a virosomal vaccine have been licensed in seasonal or pandemic influenza vaccines and are/were used successfully in the elderly. AS01, a liposome-based adjuvant comprising two immunostimulants has recently been approved in a recombinant protein vaccine for older adults, which showed very high efficacy against herpes zoster in clinical trials. Several adjuvants for use in the older population are in clinical and preclinical development and will hopefully improve vaccines for this age group in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available