Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 50, Issue -, Pages 146-153Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2018.02.006
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Funding
- National Institutes of Health [RO1 NS083875]
- National Institutes of Health (President's BRAIN Initiative) [1U01NS090565, 1U01NS103517]
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In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. As the number of GEVIs successfully tested for in vivo use grows, so has the number of open questions regarding the improvements that would facilitate broad adoption of this technology that surpasses mere 'proof of principle' studies. Our aim in this review is not to provide a status check of the current state of the field, as excellent publications covering this topic already exist. Here, we discuss specific questions regarding GEVI development and application that we think are crucial in achieving this goal.
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