Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 50, Issue -, Pages 136-145Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2018.02.004
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Funding
- NHMRC [APP1066887]
- ARC Future Fellowship [FT110100887]
- Simons Foundation [SFARI 399432]
- ARC [DP140102036, DP110103612]
- EMBO Long-term Fellowship
- Howard Hughes Medical Institute
- Australian Research Council [FT110100887] Funding Source: Australian Research Council
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Due to their small size and transparency, zebrafish larvae are amenable to a range of fluorescence microscopy techniques. With the development of sensitive genetically encoded calcium indicators, this has extended to the whole-brain imaging of neural activity with cellular resolution. This technique has been used to study brain-wide population dynamics accompanying sensory processing and sensorimotor transformations, and has spurred the development of innovative closed-loop behavioral paradigms in which stimulus-response relationships can be studied. More recently, microscopes have been developed that allow whole-brain calcium imaging in freely swimming and behaving larvae. In this review, we highlight the technologies underlying whole-brain functional imaging in zebrafish, provide examples of the sensory and motor processes that have been studied with this technique, and discuss the need to merge data from whole-brain functional imaging studies with neurochemical and anatomical information to develop holistic models of functional neural circuits.
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